Drug interactions
Fenfluramine + Tranylcypromine
Severity: Contraindicated
Fenfluramine and Tranylcypromine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine increases serotonin release and blocks its reuptake, and an MAOI blocks serotonin breakdown. This combination risks serotonin syndrome and hypertensive reactions, and labeling prohibits its use within 14 days of an MAOI.
What this interaction means in plain words
Fenfluramine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fenfluramine belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Serotonin release and reuptake inhibition combined with irreversible MAO inhibition causes serotonin excess.
What to do
Do not coadminister, and wait at least 14 days after stopping tranylcypromine before starting fenfluramine. Consider another antiseizure agent if an MAOI is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Almotriptan + Fenfluramine Major
- Amitriptyline + Fenfluramine Major
Frequently asked questions
Can I take Fenfluramine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Fenfluramine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fenfluramine increases serotonin release and blocks its reuptake, and an MAOI blocks serotonin breakdown. This combination risks serotonin syndrome and hypertensive reactions, and labeling prohibits its use within 14 days of an MAOI.
How serious is the interaction between Fenfluramine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister, and wait at least 14 days after stopping tranylcypromine before starting fenfluramine. Consider another antiseizure agent if an MAOI is needed.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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