Drug interactions
Citalopram + Idelalisib
Severity: Moderate
Citalopram and Idelalisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib strongly inhibits CYP3A4, which may raise citalopram concentrations. Higher exposure increases the risk of dose-related QT prolongation and serotonergic adverse effects.
What this interaction means in plain words
Citalopram and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Idelalisib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated citalopram metabolism by idelalisib, although CYP2C19 also contributes to clearance.
What to do
Monitor for adverse effects and ECG changes, and consider limiting the citalopram dose. Choose an alternative antidepressant if QT risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Citalopram with Idelalisib?
MediHelp rates the interaction as moderate. Citalopram and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib strongly inhibits CYP3A4, which may raise citalopram concentrations. Higher exposure increases the risk of dose-related QT prolongation and serotonergic adverse effects.
How serious is the interaction between Citalopram and Idelalisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and ECG changes, and consider limiting the citalopram dose. Choose an alternative antidepressant if QT risk is high.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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