Drug interactions
Cisapride + Idelalisib
Severity: Contraindicated
Cisapride and Idelalisib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib can raise cisapride concentrations, increasing the risk of QT prolongation and life-threatening arrhythmias such as torsades de pointes.
What this interaction means in plain words
Cisapride and Idelalisib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cisapride belongs to Gastrointestinal Tract; Idelalisib belongs to Oncology.
Why it happens
Strong CYP3A inhibition by the idelalisib metabolite GS-563117 reduces cisapride metabolism.
What to do
Do not coadminister; use a non-CYP3A prokinetic alternative.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cisapride and Idelalisib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
- Ergotamine + Idelalisib Contraindicated
Other interactions of Cisapride
- Apomorphine + Cisapride Contraindicated
- Artemether + Cisapride Contraindicated
- Azithromycin + Cisapride Contraindicated
- Ceritinib + Cisapride Contraindicated
- Chloroquine + Cisapride Contraindicated
- Cisapride + Citalopram Contraindicated
Frequently asked questions
Can I take Cisapride with Idelalisib?
MediHelp rates the interaction as contraindicated. Cisapride and Idelalisib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Idelalisib can raise cisapride concentrations, increasing the risk of QT prolongation and life-threatening arrhythmias such as torsades de pointes.
How serious is the interaction between Cisapride and Idelalisib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use a non-CYP3A prokinetic alternative.
What other medicines interact with Idelalisib?
MediHelp also lists interactions of Idelalisib with, for example, Alfuzosin, Dihydroergotamine, Dronedarone. The full list is on the Idelalisib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
