Drug interactions
Citalopram + Midostaurin
Severity: Major
Citalopram and Midostaurin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have QTc-prolonging potential, so combining them can increase risk of torsades de pointes.
What this interaction means in plain words
Citalopram and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Citalopram belongs to Central Nervous System; Midostaurin belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Avoid if alternatives exist; otherwise monitor ECG and keep potassium and magnesium normal. Consider reducing citalopram dose in at-risk patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Midostaurin
Frequently asked questions
Can I take Citalopram with Midostaurin?
MediHelp rates the interaction as major. Citalopram and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs have QTc-prolonging potential, so combining them can increase risk of torsades de pointes.
How serious is the interaction between Citalopram and Midostaurin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if alternatives exist; otherwise monitor ECG and keep potassium and magnesium normal. Consider reducing citalopram dose in at-risk patients.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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