Drug interactions
Asenapine + Midostaurin
Severity: Major
Asenapine and Midostaurin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, so concurrent use may increase the risk of ventricular arrhythmias including torsade de pointes. The risk is greater with electrolyte disturbances or underlying heart disease.
What this interaction means in plain words
Asenapine and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Asenapine belongs to Central Nervous System; Midostaurin belongs to Oncology.
Why it happens
Additive QT prolongation.
What to do
Use an alternative antipsychotic if possible. Otherwise obtain baseline and follow-up ECGs and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Midostaurin
- Alfuzosin + Midostaurin Major
- Amisulpride + Midostaurin Major
- Amobarbital + Midostaurin Major
- Anagrelide + Midostaurin Major
- Apalutamide + Midostaurin Major
- Bosentan + Midostaurin Major
Frequently asked questions
Can I take Asenapine with Midostaurin?
MediHelp rates the interaction as major. Asenapine and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QTc interval, so concurrent use may increase the risk of ventricular arrhythmias including torsade de pointes. The risk is greater with electrolyte disturbances or underlying heart disease.
How serious is the interaction between Asenapine and Midostaurin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antipsychotic if possible. Otherwise obtain baseline and follow-up ECGs and keep potassium and magnesium within normal range.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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