Drug interactions
Amobarbital + Midostaurin
Severity: Major
Amobarbital and Midostaurin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may reduce midostaurin and active metabolite concentrations by inducing CYP3A4. This may compromise efficacy in acute myeloid leukemia or mastocytosis.
What this interaction means in plain words
Amobarbital and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Midostaurin belongs to Oncology.
Why it happens
CYP3A4 induction increases clearance of midostaurin and its active metabolites.
What to do
Avoid strong CYP3A4 inducers with midostaurin and use an alternative. Monitor disease response if the combination is unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Midostaurin
- Alfuzosin + Midostaurin Major
- Amisulpride + Midostaurin Major
- Anagrelide + Midostaurin Major
- Apalutamide + Midostaurin Major
- Asenapine + Midostaurin Major
- Bosentan + Midostaurin Major
Frequently asked questions
Can I take Amobarbital with Midostaurin?
MediHelp rates the interaction as major. Amobarbital and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital may reduce midostaurin and active metabolite concentrations by inducing CYP3A4. This may compromise efficacy in acute myeloid leukemia or mastocytosis.
How serious is the interaction between Amobarbital and Midostaurin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid strong CYP3A4 inducers with midostaurin and use an alternative. Monitor disease response if the combination is unavoidable.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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