Drug interactions
Anagrelide + Midostaurin
Severity: Major
Anagrelide and Midostaurin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midostaurin can prolong the QT interval, and anagrelide has a similar effect. The combination may increase the risk of torsades de pointes.
What this interaction means in plain words
Anagrelide and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Anagrelide belongs to Cardiovascular; Midostaurin belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid if possible. If both are needed, monitor ECG and electrolytes at baseline and during therapy and consider interrupting midostaurin if QTc rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Anagrelide
- Anagrelide + Panobinostat Contraindicated
- Anagrelide + Pimozide Contraindicated
- Anagrelide + Thioridazine Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Abrocitinib + Anagrelide Major
- Alfuzosin + Anagrelide Major
Other interactions of Midostaurin
- Alfuzosin + Midostaurin Major
- Amisulpride + Midostaurin Major
- Amobarbital + Midostaurin Major
- Apalutamide + Midostaurin Major
- Asenapine + Midostaurin Major
- Bosentan + Midostaurin Major
Frequently asked questions
Can I take Anagrelide with Midostaurin?
MediHelp rates the interaction as major. Anagrelide and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Midostaurin can prolong the QT interval, and anagrelide has a similar effect. The combination may increase the risk of torsades de pointes.
How serious is the interaction between Anagrelide and Midostaurin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If both are needed, monitor ECG and electrolytes at baseline and during therapy and consider interrupting midostaurin if QTc rises significantly.
What other medicines interact with Anagrelide?
MediHelp also lists interactions of Anagrelide with, for example, Panobinostat, Pimozide, Thioridazine. The full list is on the Anagrelide page.
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