Drug interactions
Amisulpride + Midostaurin
Severity: Major
Amisulpride and Midostaurin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QTc interval, so their combination may increase the risk of ventricular arrhythmias including torsades de pointes. The risk is greater with electrolyte disturbances or cardiac disease.
What this interaction means in plain words
Amisulpride and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Midostaurin belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization (QT prolongation).
What to do
Prefer an alternative to amisulpride where possible. If both are needed, obtain a baseline and periodic ECG and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Midostaurin
- Alfuzosin + Midostaurin Major
- Amobarbital + Midostaurin Major
- Anagrelide + Midostaurin Major
- Apalutamide + Midostaurin Major
- Asenapine + Midostaurin Major
- Bosentan + Midostaurin Major
Frequently asked questions
Can I take Amisulpride with Midostaurin?
MediHelp rates the interaction as major. Amisulpride and Midostaurin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can prolong the QTc interval, so their combination may increase the risk of ventricular arrhythmias including torsades de pointes. The risk is greater with electrolyte disturbances or cardiac disease.
How serious is the interaction between Amisulpride and Midostaurin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to amisulpride where possible. If both are needed, obtain a baseline and periodic ECG and keep potassium and magnesium within normal range.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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