Drug interactions
Citalopram + Panobinostat
Severity: Major
Citalopram and Panobinostat: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and panobinostat has a clear QT-prolonging effect. Taken together they may increase the risk of torsades de pointes and other serious ventricular arrhythmias.
What this interaction means in plain words
Citalopram and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Citalopram belongs to Central Nervous System; Panobinostat belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization (QTc) through pharmacodynamic synergy.
What to do
Avoid the combination and choose an antidepressant with less QT liability, such as sertraline. If unavoidable, obtain baseline and serial ECGs and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Citalopram with Panobinostat?
MediHelp rates the interaction as major. Citalopram and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and panobinostat has a clear QT-prolonging effect. Taken together they may increase the risk of torsades de pointes and other serious ventricular arrhythmias.
How serious is the interaction between Citalopram and Panobinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antidepressant with less QT liability, such as sertraline. If unavoidable, obtain baseline and serial ECGs and keep potassium and magnesium within normal range.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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