Drug interactions
Citalopram + Pregabalin
Severity: Minor
Citalopram and Pregabalin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin causes sedation and dizziness, and citalopram may add to drowsiness and psychomotor impairment. Respiratory depression is mainly a concern in vulnerable patients or when other CNS depressants are present.
What this interaction means in plain words
Citalopram and Pregabalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Citalopram belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects, which are pharmacodynamic.
What to do
Start pregabalin low and titrate gradually, monitoring for sedation and dizziness. Take particular care in elderly patients and those taking opioids or other sedatives.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Pregabalin
Frequently asked questions
Can I take Citalopram with Pregabalin?
MediHelp rates the interaction as minor. Citalopram and Pregabalin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pregabalin causes sedation and dizziness, and citalopram may add to drowsiness and psychomotor impairment. Respiratory depression is mainly a concern in vulnerable patients or when other CNS depressants are present.
How serious is the interaction between Citalopram and Pregabalin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start pregabalin low and titrate gradually, monitoring for sedation and dizziness. Take particular care in elderly patients and those taking opioids or other sedatives.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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