Drug interactions
Citalopram + Risperidone
Severity: Moderate
Citalopram and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, risperidone modestly and citalopram in a dose-dependent manner. The combined effect may increase arrhythmia risk in patients with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Citalopram and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Risperidone belongs to Central Nervous System.
Why it happens
Additive effects on cardiac repolarization.
What to do
Use the lowest effective doses and obtain a baseline ECG in patients with risk factors. Correct potassium and magnesium and avoid further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Citalopram with Risperidone?
MediHelp rates the interaction as moderate. Citalopram and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, risperidone modestly and citalopram in a dose-dependent manner. The combined effect may increase arrhythmia risk in patients with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Citalopram and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and obtain a baseline ECG in patients with risk factors. Correct potassium and magnesium and avoid further QT-prolonging drugs.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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