Drug interactions
Citalopram + Rucaparib
Severity: Minor
Citalopram and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits several CYP enzymes including CYP2C19 and CYP3A4, which may modestly increase citalopram concentrations. Higher levels could add to QT and serotonergic adverse effects.
What this interaction means in plain words
Citalopram and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Citalopram belongs to Central Nervous System; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP2C19 and CYP3A4, reducing citalopram metabolism.
What to do
Monitor for increased adverse effects such as nausea, somnolence or palpitations. Reduce citalopram dose if these arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Citalopram with Rucaparib?
MediHelp rates the interaction as minor. Citalopram and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits several CYP enzymes including CYP2C19 and CYP3A4, which may modestly increase citalopram concentrations. Higher levels could add to QT and serotonergic adverse effects.
How serious is the interaction between Citalopram and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased adverse effects such as nausea, somnolence or palpitations. Reduce citalopram dose if these arise.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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