Drug interactions
Citalopram + Stiripentol
Severity: Moderate
Citalopram and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP2C19 and CYP3A4 and can raise citalopram concentrations, increasing the risk of dose-related effects including QT prolongation. Stiripentol also has inducing effects that make the net result variable.
What this interaction means in plain words
Citalopram and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits CYP2C19 and CYP3A4 metabolism of citalopram.
What to do
Keep citalopram at or below 20 mg/day and monitor for toxicity and QT-related symptoms. Consider an ECG if risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Other interactions of Stiripentol
Frequently asked questions
Can I take Citalopram with Stiripentol?
MediHelp rates the interaction as moderate. Citalopram and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol inhibits CYP2C19 and CYP3A4 and can raise citalopram concentrations, increasing the risk of dose-related effects including QT prolongation. Stiripentol also has inducing effects that make the net result variable.
How serious is the interaction between Citalopram and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep citalopram at or below 20 mg/day and monitor for toxicity and QT-related symptoms. Consider an ECG if risk factors are present.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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