Drug interactions
Citalopram + Tiotropium-olodaterol
Severity: Moderate
Citalopram and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citalopram causes dose-dependent QT prolongation, and beta2 agonists can add to the risk of ventricular arrhythmia via tachycardia and hypokalemia. The concern is greatest with higher citalopram doses, in older patients, or with underlying heart disease.
What this interaction means in plain words
Citalopram and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Citalopram belongs to Central Nervous System; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive QT prolongation and beta2-mediated sympathetic and potassium effects.
What to do
Keep the citalopram dose within labeled limits and check an ECG in patients with cardiac risk factors. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Citalopram with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Citalopram and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Citalopram causes dose-dependent QT prolongation, and beta2 agonists can add to the risk of ventricular arrhythmia via tachycardia and hypokalemia. The concern is greatest with higher citalopram doses, in older patients, or with underlying heart disease.
How serious is the interaction between Citalopram and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep the citalopram dose within labeled limits and check an ECG in patients with cardiac risk factors. Correct potassium and magnesium abnormalities.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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