Drug interactions
Cladribine + Danicopan
Severity: Moderate
Cladribine and Danicopan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits BCRP, and cladribine absorption and disposition depend on BCRP. Cladribine exposure may therefore increase, raising the risk of hematologic toxicity.
What this interaction means in plain words
Cladribine and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cladribine belongs to Oncology; Danicopan belongs to Miscellaneous.
Why it happens
Inhibition of the BCRP efflux transporter by danicopan increases cladribine bioavailability.
What to do
Avoid coadministration if possible, or monitor blood counts and lymphocyte counts closely. Consider cladribine dose reduction per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cladribine
- Adenovirus types 4 and 7 live + Cladribine Contraindicated
- Cladribine + Siponimod Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Axicabtagene ciloleucel + Cladribine Major
- Belatacept + Cladribine Major
- Brexucabtagene autoleucel + Cladribine Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Colchicine + Danicopan Moderate
Frequently asked questions
Can I take Cladribine with Danicopan?
MediHelp rates the interaction as moderate. Cladribine and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits BCRP, and cladribine absorption and disposition depend on BCRP. Cladribine exposure may therefore increase, raising the risk of hematologic toxicity.
How serious is the interaction between Cladribine and Danicopan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration if possible, or monitor blood counts and lymphocyte counts closely. Consider cladribine dose reduction per labeling.
What other medicines interact with Cladribine?
MediHelp also lists interactions of Cladribine with, for example, Adenovirus types 4 and 7 live, Siponimod, Tofacitinib. The full list is on the Cladribine page.
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