Drug interactions
Apixaban + Danicopan
Severity: Moderate
Apixaban and Danicopan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-gp and can increase concentrations of P-gp substrates such as apixaban. This may increase the risk of bleeding.
What this interaction means in plain words
Apixaban and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apixaban belongs to Cardiovascular; Danicopan belongs to Miscellaneous.
Why it happens
Inhibition of P-gp efflux increases apixaban absorption and reduces clearance.
What to do
Monitor for bleeding signs and consider whether the anticoagulant dose is appropriate for the patient's renal function and risk profile.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apixaban
- Apixaban + Dabigatran Contraindicated
- Apixaban + Defibrotide Contraindicated
- Apixaban + Edoxaban Contraindicated
- Apixaban + Ketorolac Contraindicated
- Apixaban + Mifepristone Contraindicated
- Abciximab + Apixaban Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
- Colchicine + Danicopan Moderate
Frequently asked questions
Can I take Apixaban with Danicopan?
MediHelp rates the interaction as moderate. Apixaban and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-gp and can increase concentrations of P-gp substrates such as apixaban. This may increase the risk of bleeding.
How serious is the interaction between Apixaban and Danicopan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and consider whether the anticoagulant dose is appropriate for the patient's renal function and risk profile.
What other medicines interact with Apixaban?
MediHelp also lists interactions of Apixaban with, for example, Dabigatran, Defibrotide, Edoxaban. The full list is on the Apixaban page.
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