Drug interactions
Atorvastatin + Danicopan
Severity: Moderate
Atorvastatin and Danicopan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-gp and BCRP, both involved in atorvastatin disposition, and may raise atorvastatin concentrations. This may increase the risk of dose-related statin muscle toxicity.
What this interaction means in plain words
Atorvastatin and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Danicopan belongs to Miscellaneous.
Why it happens
Danicopan inhibits intestinal P-glycoprotein and BCRP, increasing atorvastatin absorption.
What to do
Monitor for myalgia and consider reducing the atorvastatin dose, checking CK if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Cyclosporine Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
- Colchicine + Danicopan Moderate
Frequently asked questions
Can I take Atorvastatin with Danicopan?
MediHelp rates the interaction as moderate. Atorvastatin and Danicopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-gp and BCRP, both involved in atorvastatin disposition, and may raise atorvastatin concentrations. This may increase the risk of dose-related statin muscle toxicity.
How serious is the interaction between Atorvastatin and Danicopan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myalgia and consider reducing the atorvastatin dose, checking CK if symptoms develop.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
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