Drug interactions
Cladribine + Vadadustat
Severity: Moderate
Cladribine and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits BCRP, which governs cladribine absorption and efflux. Cladribine exposure may rise, increasing the risk of lymphopenia and other toxicity.
What this interaction means in plain words
Cladribine and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cladribine belongs to Oncology; Vadadustat belongs to Endocrine.
Why it happens
BCRP inhibition by vadadustat raises cladribine bioavailability.
What to do
Avoid the combination if possible, or monitor lymphocyte and blood counts closely. Consider reducing the cladribine dose per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cladribine
- Adenovirus types 4 and 7 live + Cladribine Contraindicated
- Cladribine + Siponimod Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Axicabtagene ciloleucel + Cladribine Major
- Belatacept + Cladribine Major
- Brexucabtagene autoleucel + Cladribine Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Cladribine with Vadadustat?
MediHelp rates the interaction as moderate. Cladribine and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits BCRP, which governs cladribine absorption and efflux. Cladribine exposure may rise, increasing the risk of lymphopenia and other toxicity.
How serious is the interaction between Cladribine and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or monitor lymphocyte and blood counts closely. Consider reducing the cladribine dose per labeling.
What other medicines interact with Cladribine?
MediHelp also lists interactions of Cladribine with, for example, Adenovirus types 4 and 7 live, Siponimod, Tofacitinib. The full list is on the Cladribine page.
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