Drug interactions
Calcium carbonate + Vadadustat
Severity: Moderate
Calcium carbonate and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium-based phosphate binders can bind vadadustat in the gut and lower its absorption. Reduced exposure may blunt its effect on hemoglobin.
What this interaction means in plain words
Calcium carbonate and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium carbonate belongs to Gastrointestinal Tract; Vadadustat belongs to Endocrine.
Why it happens
Binding of vadadustat by calcium-based phosphate binders in the gastrointestinal tract reduces absorption.
What to do
Take vadadustat at least 1 hour before or 2 hours after calcium carbonate used as a phosphate binder. Monitor hemoglobin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium carbonate
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium + Vadadustat Moderate
- Cladribine + Vadadustat Moderate
Frequently asked questions
Can I take Calcium carbonate with Vadadustat?
MediHelp rates the interaction as moderate. Calcium carbonate and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium-based phosphate binders can bind vadadustat in the gut and lower its absorption. Reduced exposure may blunt its effect on hemoglobin.
How serious is the interaction between Calcium carbonate and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take vadadustat at least 1 hour before or 2 hours after calcium carbonate used as a phosphate binder. Monitor hemoglobin.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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