Drug interactions
Calcium + Vadadustat
Severity: Moderate
Calcium and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium-based phosphate binders can bind vadadustat in the gut and lower its exposure. This may reduce its effect on hemoglobin.
What this interaction means in plain words
Calcium and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium belongs to Gastrointestinal Tract; Vadadustat belongs to Endocrine.
Why it happens
Binding of vadadustat to calcium-based phosphate binders in the gastrointestinal tract reduces absorption.
What to do
Take vadadustat at least 1 hour before or 2 hours after calcium-based phosphate binders. Monitor hemoglobin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Cladribine + Vadadustat Moderate
Frequently asked questions
Can I take Calcium with Vadadustat?
MediHelp rates the interaction as moderate. Calcium and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium-based phosphate binders can bind vadadustat in the gut and lower its exposure. This may reduce its effect on hemoglobin.
How serious is the interaction between Calcium and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take vadadustat at least 1 hour before or 2 hours after calcium-based phosphate binders. Monitor hemoglobin.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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