Drug interactions
Clarithromycin + Daunorubicin
Severity: Moderate
Clarithromycin and Daunorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may increase daunorubicin exposure, potentially worsening myelosuppression, mucositis and cardiotoxicity. The interaction is mainly predicted from transporter inhibition and has limited clinical data.
What this interaction means in plain words
Clarithromycin and Daunorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Daunorubicin belongs to Oncology.
Why it happens
Clarithromycin inhibits P-glycoprotein, reducing efflux and clearance of daunorubicin.
What to do
Monitor blood counts and signs of mucositis and cardiac toxicity. Prefer a non-inhibiting antibiotic during chemotherapy where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
- Daunorubicin + Fingolimod Major
Frequently asked questions
Can I take Clarithromycin with Daunorubicin?
MediHelp rates the interaction as moderate. Clarithromycin and Daunorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may increase daunorubicin exposure, potentially worsening myelosuppression, mucositis and cardiotoxicity. The interaction is mainly predicted from transporter inhibition and has limited clinical data.
How serious is the interaction between Clarithromycin and Daunorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of mucositis and cardiac toxicity. Prefer a non-inhibiting antibiotic during chemotherapy where possible.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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