Drug interactions
Clarithromycin + Drospirenone
Severity: Minor
Clarithromycin and Drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone is not a significant inhibitor of CYP3A4 and is not expected to change clarithromycin levels. Conversely, clarithromycin may modestly raise drospirenone exposure, which has little practical impact except for potassium effects in susceptible patients.
What this interaction means in plain words
Clarithromycin and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clarithromycin belongs to Anti Bacterial; Drospirenone belongs to Endocrine.
Why it happens
No meaningful effect of drospirenone on clarithromycin; clarithromycin may weakly increase drospirenone through CYP3A4 inhibition.
What to do
No action is usually needed; monitor serum potassium in patients with renal impairment or on other potassium-raising drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Drospirenone
Frequently asked questions
Can I take Clarithromycin with Drospirenone?
MediHelp rates the interaction as minor. Clarithromycin and Drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Drospirenone is not a significant inhibitor of CYP3A4 and is not expected to change clarithromycin levels. Conversely, clarithromycin may modestly raise drospirenone exposure, which has little practical impact except for potassium effects in susceptible patients.
How serious is the interaction between Clarithromycin and Drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually needed; monitor serum potassium in patients with renal impairment or on other potassium-raising drugs.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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