Drug interactions
Clarithromycin + Ezogabine
Severity: Moderate
Clarithromycin and Ezogabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combining them may add to the risk of ventricular arrhythmia including torsades de pointes. Ezogabine is also no longer marketed in many regions.
What this interaction means in plain words
Clarithromycin and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Ezogabine belongs to Central Nervous System.
Why it happens
Additive QT prolongation through pharmacodynamic effects on cardiac repolarization.
What to do
Obtain a baseline ECG and monitor the QT interval, and correct potassium and magnesium abnormalities. Choose a non-QT-prolonging antibiotic in patients with other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clarithromycin and Ezogabine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Clarithromycin with Ezogabine?
MediHelp rates the interaction as moderate. Clarithromycin and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combining them may add to the risk of ventricular arrhythmia including torsades de pointes. Ezogabine is also no longer marketed in many regions.
How serious is the interaction between Clarithromycin and Ezogabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QT interval, and correct potassium and magnesium abnormalities. Choose a non-QT-prolonging antibiotic in patients with other risk factors.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
