Drug interactions
Clarithromycin + Fesoterodine
Severity: Moderate
Clarithromycin and Fesoterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin is a strong CYP3A4 inhibitor and raises levels of the active metabolite of fesoterodine. Anticholinergic adverse effects become more likely.
What this interaction means in plain words
Clarithromycin and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Fesoterodine belongs to Genitourinary.
Why it happens
CYP3A4 inhibition reduces clearance of the active metabolite of fesoterodine.
What to do
Limit fesoterodine to 4 mg daily during treatment with strong CYP3A4 inhibitors and monitor for anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Fesoterodine?
MediHelp rates the interaction as moderate. Clarithromycin and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin is a strong CYP3A4 inhibitor and raises levels of the active metabolite of fesoterodine. Anticholinergic adverse effects become more likely.
How serious is the interaction between Clarithromycin and Fesoterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit fesoterodine to 4 mg daily during treatment with strong CYP3A4 inhibitors and monitor for anticholinergic effects.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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