Drug interactions
Clarithromycin + Ganaxolone
Severity: Minor
Clarithromycin and Ganaxolone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is partly metabolized by CYP3A4, but labeling indicates that CYP3A4 inhibitors do not cause clinically important changes in its exposure. No meaningful interaction is expected.
What this interaction means in plain words
Clarithromycin and Ganaxolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clarithromycin belongs to Anti Bacterial; Ganaxolone belongs to Central Nervous System.
Why it happens
Possible small CYP3A4 inhibition effect on ganaxolone metabolism, not clinically significant.
What to do
No dose adjustment is required. Monitor for sedation as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Ganaxolone
Frequently asked questions
Can I take Clarithromycin with Ganaxolone?
MediHelp rates the interaction as minor. Clarithromycin and Ganaxolone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ganaxolone is partly metabolized by CYP3A4, but labeling indicates that CYP3A4 inhibitors do not cause clinically important changes in its exposure. No meaningful interaction is expected.
How serious is the interaction between Clarithromycin and Ganaxolone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor for sedation as usual.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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