Drug interactions
Clarithromycin + Glasdegib
Severity: Major
Clarithromycin and Glasdegib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin increases glasdegib exposure via CYP3A4 inhibition, and both agents can prolong the QT interval. The combination raises the risk of QT prolongation and torsades de pointes.
What this interaction means in plain words
Clarithromycin and Glasdegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Glasdegib belongs to Oncology.
Why it happens
CYP3A4 inhibition raises glasdegib levels, with additive QT prolongation.
What to do
Prefer a non-CYP3A4-inhibiting, non-QT-prolonging antibiotic. If unavoidable, monitor the ECG and electrolytes before and during co-therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Glasdegib
- Amiodarone + Glasdegib Major
- Amisulpride + Glasdegib Major
- Amobarbital + Glasdegib Major
- Anagrelide + Glasdegib Major
- Apalutamide + Glasdegib Major
- Asenapine + Glasdegib Major
Frequently asked questions
Can I take Clarithromycin with Glasdegib?
MediHelp rates the interaction as major. Clarithromycin and Glasdegib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin increases glasdegib exposure via CYP3A4 inhibition, and both agents can prolong the QT interval. The combination raises the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Clarithromycin and Glasdegib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-CYP3A4-inhibiting, non-QT-prolonging antibiotic. If unavoidable, monitor the ECG and electrolytes before and during co-therapy.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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