Drug interactions
Clarithromycin + Hydrochlorothiazide-valsartan
Severity: Minor
Clarithromycin and Hydrochlorothiazide-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan is a substrate of hepatic uptake transporters, and clarithromycin may inhibit these transporters, potentially raising valsartan exposure. The clinical effect is expected to be modest, mainly additional blood pressure lowering.
What this interaction means in plain words
Clarithromycin and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clarithromycin belongs to Anti Bacterial; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Clarithromycin may inhibit OATP1B1 and efflux transporters, reducing hepatic uptake and clearance of valsartan.
What to do
No dose change is usually required. Monitor blood pressure and for symptoms of hypotension during the course of clarithromycin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as minor. Clarithromycin and Hydrochlorothiazide-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan is a substrate of hepatic uptake transporters, and clarithromycin may inhibit these transporters, potentially raising valsartan exposure. The clinical effect is expected to be modest, mainly additional blood pressure lowering.
How serious is the interaction between Clarithromycin and Hydrochlorothiazide-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Monitor blood pressure and for symptoms of hypotension during the course of clarithromycin.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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