Drug interactions
Clarithromycin + Lumateperone
Severity: Moderate
Clarithromycin and Lumateperone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin significantly increases lumateperone exposure, raising the risk of sedation, orthostatic hypotension and other dose-related adverse effects.
What this interaction means in plain words
Clarithromycin and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Lumateperone belongs to Central Nervous System.
Why it happens
Strong CYP3A4 inhibition reduces lumateperone metabolism.
What to do
Reduce lumateperone to 10.5 mg daily during co-administration and monitor for sedation and hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Lumateperone
Frequently asked questions
Can I take Clarithromycin with Lumateperone?
MediHelp rates the interaction as moderate. Clarithromycin and Lumateperone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin significantly increases lumateperone exposure, raising the risk of sedation, orthostatic hypotension and other dose-related adverse effects.
How serious is the interaction between Clarithromycin and Lumateperone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce lumateperone to 10.5 mg daily during co-administration and monitor for sedation and hypotension.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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