Drug interactions
clarithromycin + methadone
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ methadone + additive QT → torsades/overdose risk.
Mechanism of action
CYP3A4 inhibition + QT effects.
Clinical management
Avoid or monitor ECG and methadone dose closely.
Drug reference
References
Frequently asked questions
Can I take clarithromycin with methadone?
The interaction is rated: Major. ↑ methadone + additive QT → torsades/overdose risk.
How serious is the interaction between clarithromycin and methadone?
The interaction is rated: Major. Evidence level: High.
How is the interaction between clarithromycin and methadone managed?
Avoid or monitor ECG and methadone dose closely.
Why do clarithromycin and methadone interact?
CYP3A4 inhibition + QT effects.
Full monographs, dosing and an interaction checker in the MediHelp app
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