Drug interactions
Clarithromycin + Netupitant-palonosetron
Severity: Minor
Clarithromycin and Netupitant-palonosetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin is a strong CYP3A4 inhibitor and can raise netupitant concentrations. Netupitant is given as a single dose per chemotherapy cycle, and the label does not require adjustment with CYP3A4 inhibitors.
What this interaction means in plain words
Clarithromycin and Netupitant-palonosetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clarithromycin belongs to Anti Bacterial; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP3A4-mediated netupitant metabolism.
What to do
No dose adjustment is needed. Monitor for netupitant adverse effects such as headache, constipation and fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clarithromycin and Netupitant-palonosetron, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Netupitant-palonosetron?
MediHelp rates the interaction as minor. Clarithromycin and Netupitant-palonosetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clarithromycin is a strong CYP3A4 inhibitor and can raise netupitant concentrations. Netupitant is given as a single dose per chemotherapy cycle, and the label does not require adjustment with CYP3A4 inhibitors.
How serious is the interaction between Clarithromycin and Netupitant-palonosetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for netupitant adverse effects such as headache, constipation and fatigue.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
