Drug interactions
Clarithromycin + Pazopanib
Severity: Major
Clarithromycin and Pazopanib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin raises pazopanib concentrations, increasing the risk of hepatotoxicity, hypertension and QT prolongation. Both drugs also have QT effects.
What this interaction means in plain words
Clarithromycin and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Pazopanib belongs to Oncology.
Why it happens
Strong CYP3A4 (and P-gp) inhibition reduces pazopanib clearance, with additive QT effects.
What to do
Avoid the combination and choose a non-interacting antibiotic. If necessary, reduce pazopanib to 400 mg daily and monitor liver tests and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Clarithromycin with Pazopanib?
MediHelp rates the interaction as major. Clarithromycin and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin raises pazopanib concentrations, increasing the risk of hepatotoxicity, hypertension and QT prolongation. Both drugs also have QT effects.
How serious is the interaction between Clarithromycin and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-interacting antibiotic. If necessary, reduce pazopanib to 400 mg daily and monitor liver tests and ECG.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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