Drug interactions
Clarithromycin + Praziquantel
Severity: Minor
Clarithromycin and Praziquantel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may increase praziquantel concentrations because praziquantel undergoes extensive CYP3A4 first-pass metabolism. This could increase dose-related adverse effects such as dizziness, headache and abdominal pain.
What this interaction means in plain words
Clarithromycin and Praziquantel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clarithromycin belongs to Anti Bacterial; Praziquantel belongs to Anti Parasitic.
Why it happens
Clarithromycin inhibits CYP3A4 metabolism of praziquantel.
What to do
Usually no dose change is needed for short praziquantel courses. Monitor for increased adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Frequently asked questions
Can I take Clarithromycin with Praziquantel?
MediHelp rates the interaction as minor. Clarithromycin and Praziquantel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clarithromycin may increase praziquantel concentrations because praziquantel undergoes extensive CYP3A4 first-pass metabolism. This could increase dose-related adverse effects such as dizziness, headache and abdominal pain.
How serious is the interaction between Clarithromycin and Praziquantel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no dose change is needed for short praziquantel courses. Monitor for increased adverse effects.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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