Drug interactions
Clarithromycin + Sacubitril-valsartan
Severity: Minor
Clarithromycin and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin inhibits OATP1B1 and P-glycoprotein in addition to CYP3A4, which could modestly raise valsartan and sacubitril exposure. The clinical effect is expected to be limited, with possible additive hypotension or renal effects.
What this interaction means in plain words
Clarithromycin and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clarithromycin belongs to Anti Bacterial; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Possible inhibition of hepatic uptake transporters (OATP1B1) reducing valsartan clearance.
What to do
No routine dose change is needed. Monitor blood pressure and renal function if a prolonged course is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Clarithromycin with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Clarithromycin and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clarithromycin inhibits OATP1B1 and P-glycoprotein in addition to CYP3A4, which could modestly raise valsartan and sacubitril exposure. The clinical effect is expected to be limited, with possible additive hypotension or renal effects.
How serious is the interaction between Clarithromycin and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor blood pressure and renal function if a prolonged course is used.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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