Drug interactions
Clarithromycin + Sorafenib
Severity: Moderate
Clarithromycin and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin may modestly increase sorafenib exposure, raising the risk of toxicities such as hand-foot skin reaction, hypertension and diarrhea. Sorafenib itself can prolong the QT interval.
What this interaction means in plain words
Clarithromycin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clarithromycin belongs to Anti Bacterial; Sorafenib belongs to Oncology.
Why it happens
CYP3A4 inhibition may reduce sorafenib metabolism, though CYP3A4 is a minor pathway for it.
What to do
Monitor for sorafenib adverse effects and consider ECG monitoring. Choose a non-interacting antibiotic if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Clarithromycin with Sorafenib?
MediHelp rates the interaction as moderate. Clarithromycin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin may modestly increase sorafenib exposure, raising the risk of toxicities such as hand-foot skin reaction, hypertension and diarrhea. Sorafenib itself can prolong the QT interval.
How serious is the interaction between Clarithromycin and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sorafenib adverse effects and consider ECG monitoring. Choose a non-interacting antibiotic if possible.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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