Drug interactions
Clemastine + Finerenone
Severity: Minor
Clemastine and Finerenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Finerenone is a CYP3A4 substrate, and clemastine is listed as a weak CYP3A4 inhibitor, so finerenone exposure could rise modestly. Higher exposure may increase the risk of hyperkalemia.
What this interaction means in plain words
Clemastine and Finerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clemastine belongs to Respiratory; Finerenone belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition may reduce finerenone metabolism.
What to do
Check serum potassium when starting or changing clemastine in patients taking finerenone. Adjust the finerenone dose if potassium rises.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clemastine
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Clemastine with Finerenone?
MediHelp rates the interaction as minor. Clemastine and Finerenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Finerenone is a CYP3A4 substrate, and clemastine is listed as a weak CYP3A4 inhibitor, so finerenone exposure could rise modestly. Higher exposure may increase the risk of hyperkalemia.
How serious is the interaction between Clemastine and Finerenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium when starting or changing clemastine in patients taking finerenone. Adjust the finerenone dose if potassium rises.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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