Drug interactions
Clemastine + Modafinil
Severity: Minor
Clemastine and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating first-generation antihistamine, while modafinil promotes wakefulness, so the effects counteract one another. Modafinil may hide drowsiness without fully reversing performance impairment.
What this interaction means in plain words
Clemastine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clemastine belongs to Respiratory; Modafinil belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on CNS arousal.
What to do
Counsel on residual impairment when driving; consider a non-sedating antihistamine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Modafinil?
MediHelp rates the interaction as minor. Clemastine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clemastine is a sedating first-generation antihistamine, while modafinil promotes wakefulness, so the effects counteract one another. Modafinil may hide drowsiness without fully reversing performance impairment.
How serious is the interaction between Clemastine and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on residual impairment when driving; consider a non-sedating antihistamine.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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