Drug interactions
Clemastine + Oxycodone
Severity: Moderate
Clemastine and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating antihistamine, and with oxycodone it increases drowsiness and slows psychomotor performance. Older adults are at greater risk of confusion and falls.
What this interaction means in plain words
Clemastine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive CNS depression.
What to do
Advise patients to avoid driving and alcohol; consider a non-sedating antihistamine as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Oxycodone?
MediHelp rates the interaction as moderate. Clemastine and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clemastine is a sedating antihistamine, and with oxycodone it increases drowsiness and slows psychomotor performance. Older adults are at greater risk of confusion and falls.
How serious is the interaction between Clemastine and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving and alcohol; consider a non-sedating antihistamine as an alternative.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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