Drug interactions
Clemastine + Stiripentol
Severity: Moderate
Clemastine and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol causes somnolence and may add to the sedation produced by clemastine. This can impair alertness and coordination.
What this interaction means in plain words
Clemastine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Monitor for excess sedation and counsel on driving and alcohol; consider a non-sedating antihistamine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clemastine
Other interactions of Stiripentol
Frequently asked questions
Can I take Clemastine with Stiripentol?
MediHelp rates the interaction as moderate. Clemastine and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol causes somnolence and may add to the sedation produced by clemastine. This can impair alertness and coordination.
How serious is the interaction between Clemastine and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and counsel on driving and alcohol; consider a non-sedating antihistamine.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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