Drug interactions
Clemastine + Trazodone
Severity: Moderate
Clemastine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clemastine is a sedating first-generation antihistamine; with trazodone the sedative and psychomotor-impairing effects may be additive. Anticholinergic effects may also add to confusion in older adults.
What this interaction means in plain words
Clemastine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression via H1 antagonism and trazodone's sedative effect.
What to do
Avoid driving or hazardous tasks, and consider a non-sedating antihistamine if appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Trazodone?
MediHelp rates the interaction as moderate. Clemastine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clemastine is a sedating first-generation antihistamine; with trazodone the sedative and psychomotor-impairing effects may be additive. Anticholinergic effects may also add to confusion in older adults.
How serious is the interaction between Clemastine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid driving or hazardous tasks, and consider a non-sedating antihistamine if appropriate.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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