Drug interactions
Clemastine + Trimipramine
Severity: Moderate
Clemastine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine and clemastine are both sedating and anticholinergic, so combined use can produce marked drowsiness, dry mouth, urinary retention, constipation and confusion. Older patients are especially vulnerable.
What this interaction means in plain words
Clemastine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clemastine belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Additive H1-receptor antagonism and antimuscarinic effects.
What to do
Avoid the combination in elderly patients, or use a non-sedating antihistamine instead. Monitor for oversedation and anticholinergic toxicity and warn about driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clemastine and Trimipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Clemastine
Frequently asked questions
Can I take Clemastine with Trimipramine?
MediHelp rates the interaction as moderate. Clemastine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine and clemastine are both sedating and anticholinergic, so combined use can produce marked drowsiness, dry mouth, urinary retention, constipation and confusion. Older patients are especially vulnerable.
How serious is the interaction between Clemastine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in elderly patients, or use a non-sedating antihistamine instead. Monitor for oversedation and anticholinergic toxicity and warn about driving.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
