Drug interactions
Clevidipine + Glipizide-metformin
Severity: Minor
Clevidipine and Glipizide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydropyridine calcium channel blockers can modestly impair glucose tolerance in some patients. Clevidipine is given only as a short intravenous infusion, so any effect on glycemic control is expected to be small and transient.
What this interaction means in plain words
Clevidipine and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clevidipine belongs to Cardiovascular; Glipizide-metformin belongs to Endocrine.
Why it happens
Calcium channel blockade may slightly reduce insulin release, but the effect is weak and not well established.
What to do
Monitor blood glucose during clevidipine infusion in patients with unstable control; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Glipizide-metformin?
MediHelp rates the interaction as minor. Clevidipine and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dihydropyridine calcium channel blockers can modestly impair glucose tolerance in some patients. Clevidipine is given only as a short intravenous infusion, so any effect on glycemic control is expected to be small and transient.
How serious is the interaction between Clevidipine and Glipizide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during clevidipine infusion in patients with unstable control; no routine dose change is needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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