Drug interactions
Clevidipine + Glyburide-metformin
Severity: Minor
Clevidipine and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydropyridine calcium channel blockers may slightly impair glucose tolerance, which could reduce antidiabetic control. The effect is small and rarely significant, especially with a short-acting intravenous agent.
What this interaction means in plain words
Clevidipine and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clevidipine belongs to Cardiovascular; Glyburide-metformin belongs to Endocrine.
Why it happens
Calcium channel blockade may modestly reduce insulin secretion and glucose tolerance.
What to do
Monitor blood glucose during clevidipine infusion in patients with diabetes and adjust treatment if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Glyburide-metformin?
MediHelp rates the interaction as minor. Clevidipine and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dihydropyridine calcium channel blockers may slightly impair glucose tolerance, which could reduce antidiabetic control. The effect is small and rarely significant, especially with a short-acting intravenous agent.
How serious is the interaction between Clevidipine and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during clevidipine infusion in patients with diabetes and adjust treatment if needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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