Drug interactions
Clevidipine + Lofexidine
Severity: Moderate
Clevidipine and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clevidipine is a potent intravenous vasodilator and lofexidine lowers blood pressure and heart rate centrally. Together they may cause excessive hypotension and bradycardia.
What this interaction means in plain words
Clevidipine and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clevidipine belongs to Cardiovascular; Lofexidine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from calcium channel blockade and central alpha-2 agonism.
What to do
Titrate clevidipine carefully with continuous blood pressure and heart rate monitoring. Reduce the clevidipine rate or hold lofexidine if hypotension or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Lofexidine?
MediHelp rates the interaction as moderate. Clevidipine and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clevidipine is a potent intravenous vasodilator and lofexidine lowers blood pressure and heart rate centrally. Together they may cause excessive hypotension and bradycardia.
How serious is the interaction between Clevidipine and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate clevidipine carefully with continuous blood pressure and heart rate monitoring. Reduce the clevidipine rate or hold lofexidine if hypotension or bradycardia develops.
What other medicines interact with Lofexidine?
MediHelp also lists interactions of Lofexidine with, for example, Adagrasib, Alfuzosin, Amiodarone. The full list is on the Lofexidine page.
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