Drug interactions
Clevidipine + Nifedipine
Severity: Moderate
Clevidipine and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are dihydropyridine calcium channel blockers, so using them together duplicates therapy and can cause excessive hypotension and reflex tachycardia. The combination offers little benefit over adjusting one agent.
What this interaction means in plain words
Clevidipine and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clevidipine belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Duplicate L-type calcium channel blockade producing additive vasodilation.
What to do
Avoid routine concurrent use; when transitioning from intravenous clevidipine to oral nifedipine, titrate clevidipine down as oral effect appears. Monitor blood pressure continuously during overlap.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Nifedipine?
MediHelp rates the interaction as moderate. Clevidipine and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are dihydropyridine calcium channel blockers, so using them together duplicates therapy and can cause excessive hypotension and reflex tachycardia. The combination offers little benefit over adjusting one agent.
How serious is the interaction between Clevidipine and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use; when transitioning from intravenous clevidipine to oral nifedipine, titrate clevidipine down as oral effect appears. Monitor blood pressure continuously during overlap.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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