Drug interactions
Clevidipine + Propranolol
Severity: Moderate
Clevidipine and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clevidipine is a rapid-acting dihydropyridine calcium channel blocker given intravenously. Combined with propranolol it can add to blood pressure lowering, and beta-blockade may blunt reflex tachycardia.
What this interaction means in plain words
Clevidipine and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clevidipine belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect from calcium channel blockade and beta-adrenergic blockade.
What to do
Titrate clevidipine to blood pressure with continuous monitoring. Watch for excessive hypotension and bradycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Propranolol?
MediHelp rates the interaction as moderate. Clevidipine and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clevidipine is a rapid-acting dihydropyridine calcium channel blocker given intravenously. Combined with propranolol it can add to blood pressure lowering, and beta-blockade may blunt reflex tachycardia.
How serious is the interaction between Clevidipine and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate clevidipine to blood pressure with continuous monitoring. Watch for excessive hypotension and bradycardia.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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