Drug interactions
Clevidipine + Timolol
Severity: Moderate
Clevidipine and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clevidipine is an intravenous dihydropyridine calcium channel blocker with potent arterial vasodilation. Timolol may add to the hypotensive effect and blunt reflex tachycardia, and negative inotropy may matter in heart failure.
What this interaction means in plain words
Clevidipine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clevidipine belongs to Cardiovascular; Timolol belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering from arterial vasodilation and beta blockade.
What to do
Titrate clevidipine carefully with continuous blood pressure and heart rate monitoring. Watch for hypotension and worsening heart failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Clevidipine
Frequently asked questions
Can I take Clevidipine with Timolol?
MediHelp rates the interaction as moderate. Clevidipine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clevidipine is an intravenous dihydropyridine calcium channel blocker with potent arterial vasodilation. Timolol may add to the hypotensive effect and blunt reflex tachycardia, and negative inotropy may matter in heart failure.
How serious is the interaction between Clevidipine and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate clevidipine carefully with continuous blood pressure and heart rate monitoring. Watch for hypotension and worsening heart failure.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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