Drug interactions
Clindamycin + Letermovir
Severity: Minor
Clindamycin and Letermovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clindamycin is partly metabolized by CYP3A4, and letermovir is a moderate CYP3A inhibitor. Clindamycin exposure may rise modestly. The clinical effect is generally limited.
What this interaction means in plain words
Clindamycin and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Clindamycin belongs to Anti Bacterial; Letermovir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A-mediated clindamycin metabolism by letermovir.
What to do
No dose change is usually needed. Monitor for clindamycin adverse effects such as diarrhea and Clostridioides difficile infection.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clindamycin
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Clindamycin with Letermovir?
MediHelp rates the interaction as minor. Clindamycin and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Clindamycin is partly metabolized by CYP3A4, and letermovir is a moderate CYP3A inhibitor. Clindamycin exposure may rise modestly. The clinical effect is generally limited.
How serious is the interaction between Clindamycin and Letermovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for clindamycin adverse effects such as diarrhea and Clostridioides difficile infection.
What other medicines interact with Clindamycin?
MediHelp also lists interactions of Clindamycin with, for example, Atracurium, Cisatracurium, Microbiota. The full list is on the Clindamycin page.
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