Drug interactions
Clobazam + Clonazepam
Severity: Moderate
Clobazam and Clonazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are benzodiazepines, so using them together duplicates pharmacology and increases sedation, ataxia and the risk of respiratory depression. Tolerance and dependence concerns may also be heightened, although the combination is sometimes used deliberately in refractory epilepsy.
What this interaction means in plain words
Clobazam and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Clonazepam belongs to Central Nervous System.
Why it happens
Additive GABA-A receptor potentiation producing CNS depression.
What to do
Use only with specialist supervision and the lowest effective doses, monitoring sedation and respiratory function. Avoid abrupt withdrawal of either drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonazepam
- Calcium / magnesium / potassium / sodium oxybates + Clonazepam Contraindicated
- Clonazepam + Sodium oxybate Contraindicated
- Alfentanil + Clonazepam Major
- Alprazolam + Clonazepam Major
- Amobarbital + Clonazepam Major
- Belladonna and opium + Clonazepam Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Clonazepam?
MediHelp rates the interaction as moderate. Clobazam and Clonazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are benzodiazepines, so using them together duplicates pharmacology and increases sedation, ataxia and the risk of respiratory depression. Tolerance and dependence concerns may also be heightened, although the combination is sometimes used deliberately in refractory epilepsy.
How serious is the interaction between Clobazam and Clonazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only with specialist supervision and the lowest effective doses, monitoring sedation and respiratory function. Avoid abrupt withdrawal of either drug.
What other medicines interact with Clonazepam?
MediHelp also lists interactions of Clonazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Clonazepam page.
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