Drug interactions
Clobazam + Desogestrel-ethinyl estradiol
Severity: Moderate
Clobazam and Desogestrel-ethinyl estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clobazam is a weak CYP3A4 inducer and may lower hormonal contraceptive concentrations, risking contraceptive failure. The effect is clinically relevant at higher doses.
What this interaction means in plain words
Clobazam and Desogestrel-ethinyl estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Desogestrel-ethinyl estradiol belongs to Endocrine.
Why it happens
Weak CYP3A4 induction by clobazam increases metabolism of ethinyl estradiol and desogestrel (etonogestrel).
What to do
Recommend an additional non-hormonal contraceptive method during and for a period after clobazam therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as moderate. Clobazam and Desogestrel-ethinyl estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clobazam is a weak CYP3A4 inducer and may lower hormonal contraceptive concentrations, risking contraceptive failure. The effect is clinically relevant at higher doses.
How serious is the interaction between Clobazam and Desogestrel-ethinyl estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Recommend an additional non-hormonal contraceptive method during and for a period after clobazam therapy.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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