Drug interactions
Clobazam + Diazepam
Severity: Moderate
Clobazam and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are benzodiazepines, so combined use produces additive sedation and respiratory depression. Clobazam and diazepam also share active metabolite pathways, such as desmethyl metabolites, that prolong effects.
What this interaction means in plain words
Clobazam and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clobazam belongs to Central Nervous System; Diazepam belongs to Musculoskeletal.
Why it happens
Additive GABA-A receptor potentiation, with overlapping CYP3A4 and CYP2C19 metabolism.
What to do
Avoid unnecessary duplication of benzodiazepines, and if both are used for seizure indications, monitor sedation and breathing. Use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Clobazam with Diazepam?
MediHelp rates the interaction as moderate. Clobazam and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are benzodiazepines, so combined use produces additive sedation and respiratory depression. Clobazam and diazepam also share active metabolite pathways, such as desmethyl metabolites, that prolong effects.
How serious is the interaction between Clobazam and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary duplication of benzodiazepines, and if both are used for seizure indications, monitor sedation and breathing. Use the lowest effective doses.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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